Novel and emerging treatments for major depression
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …
one of the leading global public health problems. Although existing available …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
Single-dose psilocybin treatment for major depressive disorder: a randomized clinical trial
Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
Psilocybin desynchronizes the human brain
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …
Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial
R von Rotz, EM Schindowski, J Jungwirth… - …, 2023 - thelancet.com
Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …
depression. Two consecutive doses have been shown to markedly decrease symptom …
Human brain effects of DMT assessed via EEG-fMRI
Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
Must psilocybin always “assist psychotherapy”?
GM Goodwin, E Malievskaia… - American Journal of …, 2024 - Am Psychiatric Assoc
Design Open-label Randomized Randomized, double-blind, placebo-controlled
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …
[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of …
Background COMP360 is a proprietary, synthetic formulation of psilocybin being developed
for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high …
for treatment-resistant depression (TRD), a burdensome, life-threatening illness with high …
Adverse events in studies of classic psychedelics: A systematic review and meta-analysis
Importance A clear and comprehensive understanding of risks associated with psychedelic-
assisted therapy is necessary as investigators extend its application to new populations and …
assisted therapy is necessary as investigators extend its application to new populations and …