This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Polyploidy, or the duplication of entire genomes, has been observed in prokaryotic and
eukaryotic organisms, and in somatic and germ cells. The consequences of polyploidization …

Sturgeons seem to be frozen in time. The archaic characteristics of this ancient fish lineage
place it in a key phylogenetic position at the base of the~ 30,000 modern teleost fish …

To connect human biology to fish biomedical models, we sequenced the genome of spotted
gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome …

Whole-genome duplication (WGD) events have shaped the history of many evolutionary
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …

A simple and robust method for targeted mutagenesis in zebrafish has long been sought.
Previous methods generate monoallelic mutations in the germ line of F0 animals, usually …

Vertebrate evolution has been shaped by several rounds of whole-genome duplications
(WGDs) that are often suggested to be associated with adaptive radiations and evolutionary …

The ability to define cell types and how they change during organogenesis is central to our
understanding of animal development and human disease. Despite the crucial nature of this …

The common carp, Cyprinus carpio, is one of the most important cyprinid species and
globally accounts for 10% of freshwater aquaculture production. Here we present a draft …

Hox genes encode evolutionarily conserved transcription factors that are essential for the
proper development of bilaterian organisms. Hox genes are unique because they are …