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[HTML][HTML] Cartilage homeostasis and osteoarthritis
Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …
Adhesive hydrogels in osteoarthritis: from design to application
Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7%
of the global population and more than 500 million people worldwide. One research frontier …
of the global population and more than 500 million people worldwide. One research frontier …
Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
Osteoarthritis (OA) is a common joint disease characterized by progressive loss of cartilage
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
and reduction in lubricating synovial fluid, which lacks effective treatments currently. Here …
Three‐dimensional bioprinting biphasic multicellular living scaffold facilitates osteochondral defect regeneration
Due to tissue lineage variances and the anisotropic physiological characteristics,
regenerating complex osteochondral tissues (cartilage and subchondral bone) remains a …
regenerating complex osteochondral tissues (cartilage and subchondral bone) remains a …
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner
Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …
and anabolic processes in articular cartilage and proinflammatory changes throughout the …
Modeling human skeletal development using human pluripotent stem cells
Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …
provide insights into skeletal development and genetic skeletal disorders and will generate …
Cartilage lacuna‐inspired microcarriers drive hyaline neocartilage regeneration
Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …
Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity
Osteoarthritis is a degenerative joint disease that causes pain, degradation, and dysfunction.
Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic …
Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic …
Thermosensitive hydrogel loaded with primary chondrocyte-derived exosomes promotes cartilage repair by regulating macrophage polarization in osteoarthritis
X Sang, X Zhao, L Yan, X **, X Wang, J Wang… - Tissue engineering and …, 2022 - Springer
BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early
osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited …
osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited …
[HTML][HTML] Single-cell RNA-seq reveals transcriptomic heterogeneity and post-traumatic osteoarthritis-associated early molecular changes in mouse articular …
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that …
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that …