Abstract Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the
regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in …

Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also
in the regulation of metabolic, regenerative, and neural processes. In classic signaling …

Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

Abstract Purpose of the Review Osteoarthritis (OA) is an aging-associated and injury-
induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent …

Protein interactions are a fundamental mechanism for the generation of biological regulatory
specificity. The study of protein interactions in living cells is of particular significance …

Bimolecular fluorescence complementation (BiFC) analysis enables direct visualization of
protein interactions in living cells. The BiFC assay is based on the discoveries that two non …

Abstract Interleukin 6 (IL6) trans-signaling has emerged as a prominent regulator of immune
responses during both innate and acquired immunity. Regulation of IL6 trans-signaling is …

The visualization of protein complexes in living cells enables the examination of protein
interactions in their normal environment and the determination of their subcellular …

Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and
economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that …