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Review of pharmacotherapeutic targets in Alzheimer's disease and its management using traditional medicinal plants
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. While there is currently no …
cognitive decline, memory loss, and impaired daily functioning. While there is currently no …
[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020–2022)
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …
Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation …
Abstract In this study, N-[3-(3-amino-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-4-R-thiazol-2
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
[HTML][HTML] Benzimidazole-based schiff base hybrid scaffolds: a promising approach to develop multi-target drugs for alzheimer's disease
A series of benzimidazole-based Schiff base derivatives (1–18) were synthesized and
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
[HTML][HTML] Imidazopyridine-based thiazole derivatives as potential antidiabetic agents: synthesis, in vitro bioactivity, and in silico molecular modeling approach
A new series of thiazole derivatives (4a-p) incorporating imidazopyridine moiety was
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose …
In vitro and in silico correlation of bis-thiazole based Schiff base hybrids analogues: A computational approach develop to promising acetylcholinesterase and …
We have synthesized sixteen bis-thiazole based Schiff bases hybrid derivatives (1–16) and
evaluated against acetylcholinesterase and butyrylcholinesterase enzymes. All analogues …
evaluated against acetylcholinesterase and butyrylcholinesterase enzymes. All analogues …
[HTML][HTML] Design of a new potent Alzheimer's disease inhibitor based on QSAR, molecular docking and molecular dynamics investigations
A series of 32 molecules derived from 7-prenyloxy-2, 3-dihydroflavanone and 5‑hydroxy-7-
prenyloxy-2, 3-dihydro-flavanone possessing an inhibitory activity against the …
prenyloxy-2, 3-dihydro-flavanone possessing an inhibitory activity against the …
Synthesis and molecular docking simulation of new benzimidazole–thiazole hybrids as cholinesterase inhibitors
Dementia is a cognitive disturbance that is generally correlated with central nervous system
diseases, especially Alzheimer's disease. The limited number of medications available is …
diseases, especially Alzheimer's disease. The limited number of medications available is …
Exploring thiazole-based Schiff base analogs as potent α-glucosidase and α-amylase inhibitor: their synthesis and in-silico study
In search of potent antidiabetic agents here in this study a new series of thiazole-based
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …