Reperfusion of ischemic intestine leads to a sequence of events that paradoxically results in
tissue injury. Reperfusion following short periods of ischemia causes alterations in …

In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-
activated macrophages, has been implicated as an important mediator of the lethal effect of …

Atherosclerosis is a progressive vascular multifactorial process. The mechanisms
underlining the initiating event of atheromatous plaque formation are inflammation and …

Reperfusion of ischemic organs can result in tissue injury that is manifested as
microvascular and parenchymal cell dysfunction. Reactive oxygen metabolites and …

Highly purified human thrombin stimulates the adherence of polymorphonuclear leukocytes
(PMNs) to vascular endothelial cells (EC). When Indium-labeled PMNs were incubated with …

This report deals with the experimental production of ischemic bowel necrosis in rats by the
administration of combined bacterial lipopolysaccharide (LPS) and platelet-activating factor …

The most common causes of death in westernized societies remain heart disease and
stroke. For this reason the prevention of atherosclerosis is a major objective of modern …

Abstract CV-3988, rac-3-(Nn-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl
phosphate was shown to be a specific inhibitor of platelet activating factor (PAF). This …

Many different mediators have been implicated in allergic responses and allergic diseases.
14 It is becoming increasingly apparent that no single mediator can account for allergic …