Abstract Evaluation of tissues is a common and important aspect of translational research
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to …

Background Immunohistochemistry (IHC) is a well-established, widely accepted method in
both clinical and experimental parts of medical science. It allows receiving valuable …

T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities.
Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this …

Celastrol (CEL), an active compound isolated from the root of Tripterygium wilfordii, exhibits
broad anticancer activities. However, its poor stability, narrow therapeutic window and …

Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has
received growing interest because of its bioactive properties, including anti-inflammatory …

Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …

Context.—Novel therapeutics often target complex cellular mechanisms. Increasingly,
quantitative methods like digital tissue image analysis (tIA) are required to evaluate …

Inflammatory bowel disease (IBD) has been closely associated with immune disorders and
excessive M1 macrophage activation, which can be reversed by the M2-polarizing effect of …

Prevention of necrotic enteritis (NE), caused by Clostridium perfringens (C. perfringens), is
one of the most important goals to improve the profitability of broiler chickens. This work …

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …