One in five deaths worldwide is associated with sepsis, which is defined as organ
dysfunction caused by a dysregulated host response to infection. An increased …

Our core body temperature is held around 37∘ C by an effective internal thermoregulatory
system. However, various clinical scenarios have a more favorable outcome under external …

Endotoxin administration is commonly used to study the inflammatory response, and though
traditionally given as a bolus injection, it can be administered as a continuous infusion over …

Sepsis affects 31.5 million people worldwide. It is characterized by an intense drop in blood
pressure driving to cardiovascular morbidity and mortality. Modern supportive care has …

LPS is frequently used to induce experimental endotoxic shock, representing a standard
model of acute inflammation in mice. The resulting inflammatory response leads to …

This chapter develops a unified model predicting the whole-body response to endotoxin. We
simulate dynamics using differential equations examining the response to a …

This study develops a unified model predicting the whole-body response to endotoxin. We
simulate dynamics using differential equations examining the response to a …

One in five deaths worldwide is associated with sepsis. Sepsis is defined as organ
dysfunction caused by a dysregulated host response to infection. An increased …

Macrophages play a wide range of roles in resolving the inflammatory damage that
underlies many medical conditions, and have the ability to adopt different phenotypes in …

Serious infections and sepsis globally kill more than 1 million neonates annually. Early
detection of infections and sepsis is difficult and many false positives cause unnecessary …