Goal-directed behaviors allow animals to act to satisfy needs and desires. The outcome
devaluation task is an effective method for identifying goal-directed behaviors and …

Background and objective Emotional and cognitive impairments are common comorbidities
of chronic neuropathic pain that significantly impact the quality of life of patients. While the …

Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …

Introduction This study aimed to investigate the effect of muscle-derived stem cell (MDSC)
exosomes with overexpressed miR-214 on the regeneration and repair of rat sciatic nerve …

Highlights•Behavioral control can transition from goal-directed to habitual.•Habitual control
involves a shift in control by parallel corticostriatal circuits.•Experiences including drug …

The ability to adaptively guide behaviour requires the integration of external information with
internal motivational factors. Decision-making capabilities can be impaired by acute stress …

Stressors can initiate a cascade of central and peripheral changes that modulate
mesocorticolimbic dopaminergic circuits and, ultimately, behavioral response to rewards …

Stress reduces cognitive flexibility and dopamine D1 receptor-related activity in the prelimbic
cortex (PL), effects hypothesized to depend on reduced corticotropic releasing factor …

Chronic neuropathic pain and psychological stress interact to compromise goal‐directed
control over behaviour following mild psychological stress. The dorsomedial (DMS) and …

Objective To investigate the effects of exosomes from adipose-derived stem cells (ADSCs)
on peripheral nerve regeneration, and to find a new treatment for peripheral nerve injury …