The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Mitochondria maintain tight regulation of inner mitochondrial membrane (IMM) permeability
to sustain ATP production. Stressful events cause cellular calcium (Ca2+) dysregulation …

Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

Amyloid-β amyloidogenesis is reported to occur via a nucleated polymerization mechanism.
If this is true, the energetically unfavorable oligomeric nucleus should be very hard to detect …

Watching biological molecules provides clues to their function and regulation. Some of the
most powerful methods of labeling proteins for imaging use genetically encoded fluorescent …

As 2 O 3 cures acute promyelocytic leukemia (APL) by initiating PML/RARA oncoprotein
degradation, through sumoylation of its PML moiety. However, how As 2 O 3 initiates PML …

Metals are essential components in life processes and participate in many important
biological processes. Dysregulation of metal homeostasis is correlated with many diseases …