Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …

NAD+ is one of the most important metabolites for cellular activities, and its biosynthesis
mainly occurs through the salvage pathway using the nicotinamide phosphoribosyl …

Pancreatic adenocarcinomas (PDAC) often possess mutations in K-Ras that stimulate the
ERK pathway. Aberrantly high ERK activation triggers oncogene-induced senescence …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes due
to frequent recurrence, metastasis, and resistance to treatment. A major contributor to this …

The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a
hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and …

AUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their
degradation by mitophagy. This study unveils the potential of biguanides as cancer cell …

Pancreatic ductal adenocarcinoma (PDAC) is the prototypical aggressive cancer that
develops in nutrient-deficient and hypoxic microenvironment. PDAC overcomes these …

Abstract Background/Objectives: Cancer cells rely on metabolic reprogramming that is
supported by altered mitochondrial redox status and an increased demand for NAD+. Over …

There is substantial evidence from clinical and preclinical studies suggesting an association
between metformin use and a reduced risk of cancer. However, the effects of metformin use …

Pancreatic cancer (PC) is a fatal malignant disease. It is well known that the relationship
between PC and type 2 diabetes mellitus (T2DM) is a complicated bidirectional relationship …