Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

The left atrium is considered a biomarker for adverse cardiovascular outcomes, particularly
in patients with left ventricular diastolic dysfunction and atrial fibrillation in whom left atrial …

Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Cardiac fibrosis is strongly associated with obesity and metabolic dysfunction and may
contribute to the increased incidence of heart failure, atrial arrhythmias, and sudden cardiac …

Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological
changes that have occurred in response to specific stressors. These changes include …

Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to
specific mineralocorticoid receptors located in the cytosol of target epithelial cells …