In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Cannabis is the most commonly used substance of abuse in the United States after alcohol
and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

This paper reviews recent developments in the neurocircuitry and neurobiology of addiction
from a perspective of allostasis. A model is proposed for brain changes that occur during the …

Understanding the neurobiological mechanisms of addiction requires an integration of basic
neuroscience with social psychology, experimental psychology, and psychiatry. Addiction is …

Immunohistochemical distribution of cannabinoid receptors in the adult rat brain was studied
using specific purified antibodies against the amino-terminus of the CB1 receptor. Our …

Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and
take drugs and has been linked to dysregulation of brain regions that mediate reward and …

The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …

The active compound in herbal cannabis, Δ9‐tetrahydrocannabinol, exerts all of its known
central effects through the CB1 cannabinoid receptor. Research on cannabinoid …

Cannabinoids have a long history of consumption for recreational and medical reasons. The
primary active constituent of the hemp plant Cannabis sativa is Δ9-tetrahydrocannabinol (Δ9 …