Simple Summary Liquid biopsy provides important information through the analysis of
circulating tumour cells (CTCs) and circulating tumour-derived material, such as circulating …

Tumour heterogeneity is pervasive amongst many cancers and leads to disease
progression, and therapy resistance. In this review, using breast cancer as an exemplar, we …

Breast cancer is a malignant condition characterized by the uncontrolled growth of abnormal
cells in breast tissues, often forming a lump or mass that can be detected through screening …

Accurately obtaining information on the heterogeneity of CTCs at the single-cell level is a
very challenging task that may facilitate cancer pathogenesis research and personalized …

Highlights•Liquid biopsy as a potential noninvasive prognostic and predictive tool for
TNBC.•Liquid biopsy can detect early relapse and monitor metastatic disease biology.• …

Simple Summary Cancer remains one of the leading causes of death worldwide due to
widespread metastasis. Circulating tumor cells (CTCs) were first detected in 1886 and have …

Chromosomal Instability (CIN) is a common and evolving feature in breast cancer. Large-
scale Transitions (LSTs), defined as chromosomal breakages leading to gains or losses of at …

The spread of tumor cells throughout the body by traveling through the bloodstream is a
critical step in metastasis, which continues to be the main cause of cancer-related death …

Circulating tumor cell (CTC) numbers in the blood of cancer patients can indicate the
progression and invasiveness of tumors, and their prognostic and predictive value has been …

Circulating tumor DNA (ctDNA) is the cornerstone of liquid biopsy diagnostics, revealing
clinically relevant genomic aberrations from blood of cancer patients. Genomic analysis of …