Cortico-limbic interactions mediate adaptive and maladaptive responses relevant to psychopathology
Cortico-limbic circuits provide a substrate for adaptive behavioral and emotional responses.
However, dysfunction of these circuits can result in maladaptive responses that are …
However, dysfunction of these circuits can result in maladaptive responses that are …
Advances in the study of phencyclidine-induced schizophrenia-like animal models and the underlying neural mechanisms
D Li, Q Pan, Y **ao, K Hu - Schizophrenia, 2024 - nature.com
Schizophrenia (SZ) is a chronic, severe mental disorder with heterogeneous clinical
manifestations and unknown etiology. Research on SZ has long been limited by the low …
manifestations and unknown etiology. Research on SZ has long been limited by the low …
Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia
D Mattei, A Djodari-Irani, R Hadar, A Pelz… - Brain, behavior, and …, 2014 - Elsevier
Adult neurogenesis in the hippocampus is impaired in schizophrenic patients and in an
animal model of schizophrenia. Amongst a plethora of regulators, the immune system has …
animal model of schizophrenia. Amongst a plethora of regulators, the immune system has …
[HTML][HTML] Increased hippocampal CA1 cerebral blood volume in schizophrenia
Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However,
there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied …
there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied …
Deep brain stimulation for obsessive-compulsive disorder: real world experience post-FDA-humanitarian use device approval
Background: While case series have established the efficacy of deep brain stimulation
(DBS) in treating obsessive-compulsive disorder (OCD), it has been our experience that few …
(DBS) in treating obsessive-compulsive disorder (OCD), it has been our experience that few …
The complexity of ventral CA1 and its multiple functionalities
I Hong, BK Kaang - Genes, Brain and Behavior, 2022 - Wiley Online Library
The hippocampus is one of the most widely investigated brain regions with its massive
contributions to multiple behaviours. Especially, the hippocampus is subdivided into the …
contributions to multiple behaviours. Especially, the hippocampus is subdivided into the …
Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia
Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not
adequately responding to treatment. Deep brain stimulation (DBS) is a surgical technique …
adequately responding to treatment. Deep brain stimulation (DBS) is a surgical technique …
Differentiating patients with schizophrenia from healthy controls by hippocampal subfields using radiomics
Background Accurately diagnosing schizophrenia is still challenging due to the lack of
validated biomarkers. Here, we aimed to investigate whether radiomic features in bilateral …
validated biomarkers. Here, we aimed to investigate whether radiomic features in bilateral …
Schizophrenia and neurosurgery: A dark past with hope of a brighter future
Schizophrenia is a chronic and progressive psychiatric disease that remains difficult to
manage in the 21st century. Current medical therapies have been able to give reprieve and …
manage in the 21st century. Current medical therapies have been able to give reprieve and …
Volumetric and morphological characteristics of the hippocampus are associated with progression to schizophrenia in patients with first-episode psychosis
R Sauras, A Keymer, A Alonso-Solis, A Díaz… - European …, 2017 - cambridge.org
Background: Abnormalities in the hippocampus have been implicated in the
pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a …
pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a …