The studies of psychedelics, especially psychedelic tryptamines like psilocybin, are rapidly
gaining interest in neuroscience research. Much of this interest stems from recent clinical …

Abstract Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …

Spinocerebellar ataxia type 3 (SCA3) is an adult-onset neurodegenerative disease caused
by a polyglutamine expansion in the ataxin-3 (ATXN3) gene. No effective treatment is …

Background Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of
autosomal dominantly inherited spinocerebellar ataxias (SCAs). No validated blood …

Abstract Spinocerebellar ataxia type 3 (SCA3) is a fatal, late-onset neurodegenerative
disorder characterized by selective neuropathology in the brainstem, cerebellum, spinal …

Background No treatment exists for the most common dominantly inherited ataxia Machado‐
Joseph disease, or spinocerebellar ataxia type 3 (SCA3). Successful evaluation of …

Abstract Background Machado–Joseph disease (MJD), also known as spinocerebellar
ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is …

While still in preclinical testing stages, antisense oligonucleotides, short hairpin RNAs and
citalopram all show promise to reaching testing in clinical trials for MJD/SCA3. Two …

Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive
neurodegenerative disorder that affects movement coordination leading to a premature …

The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies for neurodegenerative diseases, including …