Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2019 - pubs.rsc.org
Covering: January to December 2017 This review covers the literature published in 2017 for
marine natural products (MNPs), with 740 citations (723 for the period January to December …

A quick guide to small-molecule inhibitors of eukaryotic protein synthesis

SE Dmitriev, DO Vladimirov, KA Lashkevich - Biochemistry (Moscow), 2020 - Springer
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

Computational methodologies in the exploration of marine natural product leads

F Pereira, J Aires-de-Sousa - Marine drugs, 2018 - mdpi.com
Computational methodologies are assisting the exploration of marine natural products
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …

[PDF][PDF] Natural product reports

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Nat. Prod. Rep, 2019 - vliz.be
This review covers the literature published in 2017 for marine natural products (MNPs), with
740 citations (723 for the period January to December 2017) referring to compounds …

Marine natural products with high anticancer activities

D Matulja, K Wittine, N Malatesti… - Current medicinal …, 2020 - ingentaconnect.com
This review covers recent literature from 2012-2019 concerning 170 marine natural products
and their semisynthetic analogues with strong anticancer biological activities. Reports that …

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

MF Juette, JD Carelli, EJ Rundlet, A Brown, S Shao… - Elife, 2022 - elifesciences.org
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the
correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity …

[HTML][HTML] The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies

W Zhang, J Wang, C Shan - Pharmacological Research, 2024 - Elsevier
Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic
cells. Evolutionarily conserved across species, eEF1A is in charge of translation elongation …

Drug repositioning: current approaches and their implications in the precision medicine era

A Talevi - Expert Review of Precision Medicine and Drug …, 2018 - Taylor & Francis
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It
represents a cost-efficient approach, since the new indications are built on the basis of …

Natural products as drugs and tools for influencing core processes of eukaryotic mRNA translation

LD Burgers, R Fürst - Pharmacological Research, 2021 - Elsevier
Eukaryotic protein synthesis is the highly conserved, complex mechanism of translating
genetic information into proteins. Although this process is essential for cellular …

Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo

Y Hou, R Liu, M **a, C Sun, B Zhong, J Yu, N Ai… - Pharmacological …, 2021 - Elsevier
Colorectal cancer (CRC) is one of the most common causes of cancer-related death
worldwide. Nannocystin ax (NAN), a 21-membered cyclodepsipeptide initially isolated from …