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Marine natural products
Covering: January to December 2017 This review covers the literature published in 2017 for
marine natural products (MNPs), with 740 citations (723 for the period January to December …
marine natural products (MNPs), with 740 citations (723 for the period January to December …
A quick guide to small-molecule inhibitors of eukaryotic protein synthesis
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
Computational methodologies in the exploration of marine natural product leads
Computational methodologies are assisting the exploration of marine natural products
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …
[PDF][PDF] Natural product reports
This review covers the literature published in 2017 for marine natural products (MNPs), with
740 citations (723 for the period January to December 2017) referring to compounds …
740 citations (723 for the period January to December 2017) referring to compounds …
Marine natural products with high anticancer activities
This review covers recent literature from 2012-2019 concerning 170 marine natural products
and their semisynthetic analogues with strong anticancer biological activities. Reports that …
and their semisynthetic analogues with strong anticancer biological activities. Reports that …
Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the
correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity …
correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity …
[HTML][HTML] The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies
Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic
cells. Evolutionarily conserved across species, eEF1A is in charge of translation elongation …
cells. Evolutionarily conserved across species, eEF1A is in charge of translation elongation …
Drug repositioning: current approaches and their implications in the precision medicine era
A Talevi - Expert Review of Precision Medicine and Drug …, 2018 - Taylor & Francis
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It
represents a cost-efficient approach, since the new indications are built on the basis of …
represents a cost-efficient approach, since the new indications are built on the basis of …
Natural products as drugs and tools for influencing core processes of eukaryotic mRNA translation
LD Burgers, R Fürst - Pharmacological Research, 2021 - Elsevier
Eukaryotic protein synthesis is the highly conserved, complex mechanism of translating
genetic information into proteins. Although this process is essential for cellular …
genetic information into proteins. Although this process is essential for cellular …
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo
Colorectal cancer (CRC) is one of the most common causes of cancer-related death
worldwide. Nannocystin ax (NAN), a 21-membered cyclodepsipeptide initially isolated from …
worldwide. Nannocystin ax (NAN), a 21-membered cyclodepsipeptide initially isolated from …