siRNA drug delivery across the blood–brain barrier in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …
approved drugs that provide modest symptomatic benefits and only two FDA-approved …
The contribution of small vessel disease to neurodegeneration: focus on Alzheimer's disease, Parkinson's disease and multiple sclerosis
Brain small vessel disease (SVD) refers to a variety of structural and functional changes
affecting small arteries and micro vessels, and manifesting as white matter changes …
affecting small arteries and micro vessels, and manifesting as white matter changes …
Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia …
Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …
Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort
Background White matter hyperintensities (WMH) of presumed vascular origin have been
associated with an increased risk of Alzheimer's disease (AD). This study aims to describe …
associated with an increased risk of Alzheimer's disease (AD). This study aims to describe …
Physiological and pathological remodeling of cerebral microvessels
PP Tregub, AS Averchuk, TI Baranich… - International Journal of …, 2022 - mdpi.com
There is growing evidence that the remodeling of cerebral microvessels plays an important
role in plastic changes in the brain associated with development, experience, learning, and …
role in plastic changes in the brain associated with development, experience, learning, and …
Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment …
RP Sawyer, BB Worrall, VJ Howard… - Journal of the …, 2023 - Am Heart Assoc
Background Non‐Hispanic Black adults have a higher proportion of vascular cognitive
impairment and Alzheimer's disease and related dementias compared with non‐Hispanic …
impairment and Alzheimer's disease and related dementias compared with non‐Hispanic …
[HTML][HTML] The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle-and old-aged individuals
Positive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein
E) genotype have been reported in Alzheimer's disease, but show conflicting results. We …
E) genotype have been reported in Alzheimer's disease, but show conflicting results. We …
[HTML][HTML] Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study
Background First-degree relatives of people with dementia (FH+) are at increased risk of
develo** Alzheimer's disease (AD). Here, we investigate “estimated years to onset of …
develo** Alzheimer's disease (AD). Here, we investigate “estimated years to onset of …
Hippocampal subfield volumes in middle-aged adults at risk of dementia
Background: Alzheimer's disease (AD) begins decades before the onset of dementia. There
is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early …
is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early …
Family history of dementia and brain health in childhood and middle age: a prospective community-based study
We aimed to determine the association of family history of dementia with structural brain
measures and cognitive performance in childhood and mid-life adulthood. We studied 1,259 …
measures and cognitive performance in childhood and mid-life adulthood. We studied 1,259 …