An evolutionarily conserved feature of cellular organelles is the distinct phospholipid
composition of their bounding membranes, which is essential to their identity and function …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

The internal organization of eukaryotic cells into functionally specialized, membrane-
delimited organelles of unique composition implies a need for active, regulated lipid …

Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …

INTRODUCTION During preimplantation development, the establishment of apicobasal cell
polarity is key for the transition from totipotency to pluripotency, which induces cell …

Polarization is a fundamental cellular property, which is essential for the function of
numerous cell types. Over the past three to four decades, research using the best …

Immune cells exhibit stimulation-dependent traveling waves in the cortex, much faster than
typical cortical actin waves. These waves reflect rhythmic assembly of both actin machinery …

Protein self-assemblies modulate protein activities over biological timescales that can
exceed the lifetimes of the proteins or even the cells that harbor them. We hypothesized that …

Understanding the protein composition of the inner nuclear membrane (INM) is fundamental
to elucidating its role in normal nuclear function and in disease; however, few tools exist to …

Establishment of cell polarity—or symmetry breaking—relies on local accumulation of
polarity regulators. Although simple positive feedback is sufficient to drive symmetry …