Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review

MJ Zorriehzahra, ST Delshad, M Adel, R Tiwari… - Veterinary …, 2016 - Taylor & Francis
Wide and discriminate use of antibiotics has resulted in serious biological and ecological
concerns, especially the emergence of antibiotic resistance. Probiotics, known as beneficial …

Quorum sensing inhibitors: an overview

VC Kalia - Biotechnology advances, 2013 - Elsevier
Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the
emergence of multiple drug resistant strains. Most infectious diseases are caused by …

Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options

M Chatterjee, CP Anju, L Biswas, VA Kumar… - International Journal of …, 2016 - Elsevier
Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible
for∼ 10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic …

Antibiotic discovery: combatting bacterial resistance in cells and in biofilm communities

A Penesyan, M Gillings, IT Paulsen - Molecules, 2015 - mdpi.com
Bacterial resistance is a rapidly escalating threat to public health as our arsenal of effective
antibiotics dwindles. Therefore, there is an urgent need for new antibiotics. Drug discovery …

Quorum sensing inhibitors as anti-biofilm agents

G Brackman, T Coenye - Current pharmaceutical design, 2015 - ingentaconnect.com
Biofilms are microbial sessile communities characterized by cells that are attached to a
substratum or interface or to each other, are embedded in a self-produced matrix of …

The role of flavonoids in root–rhizosphere signalling: opportunities and challenges for improving plant–microbe interactions

S Hassan, U Mathesius - Journal of experimental botany, 2012 - academic.oup.com
The flavonoid pathway produces a diverse array of plant compounds with functions in UV
protection, as antioxidants, pigments, auxin transport regulators, defence compounds …

Phytogenic compounds as alternatives to in-feed antibiotics: potentials and challenges in application

C Yang, MAK Chowdhury, Y Hou, J Gong - Pathogens, 2015 - mdpi.com
This article summarizes current experimental knowledge on the efficacy, possible
mechanisms and feasibility in the application of phytogenic products as feed additives for …

Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors

JE Paczkowski, S Mukherjee, AR McCready… - Journal of Biological …, 2017 - ASBMB
Quorum sensing is a process of cell-cell communication that bacteria use to regulate
collective behaviors. Quorum sensing depends on the production, detection, and group …