Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

J Lee, MC Woodruff, EH Kim, JH Nam - Experimental & molecular …, 2023 - nature.com
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

[HTML][HTML] COVID-19 vaccine acceptance among vulnerable groups: Syrian refugees in Jordan

QM Talafha, A Al-Haidose, AY AlSamman, SA Abdallah… - Vaccines, 2022 - mdpi.com
Despite the wide distribution of COVID-19 vaccines, refugees remain last in line for the
intake of vaccines. Syrian refugees in Jordan reach up to 700,000 registered and almost up …

Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiency

L Göschl, D Mrak… - Frontiers in …, 2022 - frontiersin.org
Background Patients with inborn errors of immunity (IEI) are at increased risk for severe
courses of SARS-CoV-2 infection. COVID-19 vaccination provides effective protection in …

SARS-CoV-2 epitopes inform future vaccination strategies

A Shafqat, MH Omer, O Ahmad, M Niaz… - Frontiers in …, 2022 - frontiersin.org
All currently approved COVID-19 vaccines utilize the spike protein as their immunogen.
SARS-CoV-2 variants of concern (VOCs) contain mutations in the spike protein, enabling …

[HTML][HTML] COVID-19 breakthrough infections in vaccinated kidney transplant recipients

X Zhang, R Weng, F Liu, Y **e, Y **, Q Li, G Huang… - Vaccines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is associated with increased morbidity and mortality
among kidney transplant recipients (KTRs). The administration of the severe acute …

[HTML][HTML] SARS-CoV-2 Vaccination: What Can We Expect Now?

F Meurens, F Renois, A Bouin, J Zhu - Vaccines, 2022 - mdpi.com
At the beginning of summer 2022, my colleagues and I wanted to share some thoughts
about a vaccination success story, ie, the first messenger RNA (mRNA) vaccines against …