Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics

X Bian, L Zhou, Z Luo, G Liu, Z Hang, H Li, F Li… - ACS nano, 2025 - ACS Publications
Nucleic acid therapeutics represent a highly promising treatment approach in modern
medicine, treating diseases at the genetic level. However, these therapeutics face numerous …

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging

A Kostyusheva, E Romano, N Yan, M Lopus… - Advanced Drug Delivery …, 2025 - Elsevier
Exosomes have emerged as promising tools for targeted drug delivery in biomedical
applications and medicine. This review delves into the scientific advancements, challenges …

Engineering Cellular Vesicles for Immunotherapy

X Lin, L Yue, K Cheng, L Rao - Accounts of Materials Research, 2025 - ACS Publications
Conspectus Immunotherapy has become a crucial strategy for cancer and infectious
diseases due to its ability to leverage the power of the immune system to combat diseases …

Antibody screening-assisted multichannel nanoplasmonic sensing chip based on SERS for viral screening and variants identification

Y Liu, H Weng, Z Chen, M Zong, S Fang, Z Wang… - Biosensors and …, 2025 - Elsevier
The Omicron variants of SARS-CoV-2 have been spreading globally and have never
disappeared from our sight, indicating that their coexistence with humans has become a fact …

NK cell membrane/MnO2 hybrid nanoparticle-adjuvanted intranasal vaccines synergistically boost protective immunity against H1N1 influenza infection

H Cheng, L Shen, X Liu, J Huo, S Wang, Q Niu… - Chemical Engineering …, 2024 - Elsevier
Intranasal vaccines hold a huge promise for preventing influenza infection, however, their
development is compromised due to mucosal barriers and limited systemic and mucosal …

Exosomes and SARS-CoV-2 infection

L Li, Z Yang, J Li - Frontiers in Immunology, 2024 - frontiersin.org
Exosomes, which are small extracellular vesicles, are of particular interest in studies on
SARS-CoV-2 infection because of their crucial role in intercellular communication. These …

Unveiling the role of nanoparticle-based therapeutic strategies for pulmonary drug delivery

PA Singh, RP Pandey, R Awasthi - Journal of Drug Delivery Science and …, 2024 - Elsevier
Pulmonary diseases are severe clinical conditions marked by widespread inflammation in
the lungs, leading to impaired gas exchange, respiratory failure, and significant mortality …

[HTML][HTML] Packaging of humanized anti-HER2 monoclonal antibody into small extracellular vesicles

J Mai, Y Zhang, Z Liang, W Xu, Q Shao, J Peng… - Extracellular …, 2025 - Elsevier
Small extracellular vesicles (sEVs), including exosomes and microvesicles (MVs), are nano-
sized membranous particles shed by almost all cell types. Both play significant roles in …

[HTML][HTML] Therapeutic potential of extracellular vesicles in inflammatory diseases

X Huang, S Zhang, Z Wang - Extracellular Vesicle, 2025 - Elsevier
Extracellular vesicles are spherical lipid bilayer vesicles composed of lipids, proteins and
nucleic acids that could deliver signaling molecules into target cells to regulate their function …

[HTML][HTML] Novel administration strategies for tissue-specific delivery of extracellular vesicles

J Deng, Q Li, F Wang - Extracellular Vesicle, 2024 - Elsevier
Extracellular vesicles (EVs) are nanoparticles released by cells with bilayer lipid membranes
that have been demonstrated to regulate biological activities. The potential of EVs as a novel …