Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Cellular iron, at the physiological level, is essential to maintain several metabolic pathways,
while an excess of free iron may cause oxidative damage and/or provoke cell death …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that
specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in …

Ferroptosis is a regulated cell death characterized by a lethal accumulation of lipid
peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity …

Many patients with heart failure have an iron‐deficient state, which can limit erythropoiesis in
erythroid precursors and ATP production in cardiomyocytes. Yet, treatment with sodium …

Background and Aims Iron is essential yet also highly chemically reactive and potentially
toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer
host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor …