[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
Pyroptosis, inflammasome, and gasdermins in tumor immunity
X Ouyang, J Zhou, L Lin, Z Zhang, S Luo… - Innate …, 2023 - journals.sagepub.com
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A
(GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD) …
(GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD) …
Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome
The inflammatory response is a complex regulated effector mechanism of the innate immune
system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an …
system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an …
Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates
Severe influenza kills tens of thousands of individuals each year, yet the mechanisms
driving lethality in humans are poorly understood. Here we used a unique translational …
driving lethality in humans are poorly understood. Here we used a unique translational …
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and
caspase-5 in humans, is upregulated during inflammatory processes and activated in …
caspase-5 in humans, is upregulated during inflammatory processes and activated in …
COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death
The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a
critical shortage of proven treatment options and an urgent need to understand the …
critical shortage of proven treatment options and an urgent need to understand the …
Role of gasdermin family proteins in cancers
X Yang, Z Tang - International Journal of Oncology, 2023 - spandidos-publications.com
The gasdermin (GSDM) family comprises six proteins, including GSDMA‑GSDME and
Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular …
Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular …
Inflammasome activation in pulmonary arterial hypertension
Inflammasomes are multi-protein complexes that sense both infectious and sterile
inflammatory stimuli, launching a cascade of responses to propagate danger signaling …
inflammatory stimuli, launching a cascade of responses to propagate danger signaling …
Position-specific secondary acylation determines detection of lipid A by murine TLR4 and caspase-11
Immune sensing of the Gram-negative bacterial membrane glycolipid lipopolysaccharide
(LPS) is both a critical component of host defense against bacterial infection and a …
(LPS) is both a critical component of host defense against bacterial infection and a …
Shigella OspC3 suppresses murine cytosolic LPS sensing
Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-
secreted effector proteins to evade host cell defenses. Caspase-11 and its human ortholog …
secreted effector proteins to evade host cell defenses. Caspase-11 and its human ortholog …