Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Highlights•Osteocytes regulate bone formation through a number of interacting signalling
pathways.•Osteocytes regulate bone resorption through controlling osteoclast activity and …

Abstract Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which
belong to the TGF-β superfamily. These glycoproteins act as a disulfide-linked homo-or …

Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

MicroRNAs (miRNAs) are regarded as a potential method for the treatment of atrial
fibrillation (AF) although its molecular mechanism remains unknown. We found in our …

The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and
directing intracellular signaling cascades in response to external stimuli. When primary cilia …

Mechanical loading opens connexin 43 (Cx43) hemichannels (HCs), leading to the release
of bone anabolic molecules, such as prostaglandins, from mechanosensitive osteocytes …

Although the skeleton is one of the predominant sites for breast cancer metastasis, why
breast cancer cells often become dormant after homing to bone is not well understood. Here …