Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Intercommunication between metal ions and amyloidogenic peptides or proteins in protein misfolding disorders

JM Suh, M Kim, J Yoo, J Han, C Paulina… - Coordination Chemistry …, 2023 - Elsevier
The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Current understanding of metal-dependent amyloid-β aggregation and toxicity

Y Yi, MH Lim - RSC Chemical Biology, 2023 - pubs.rsc.org
The discovery of effective therapeutics targeting amyloid-β (Aβ) aggregates for Alzheimer's
disease (AD) has been very challenging, which suggests its complicated etiology associated …

Multifunctional role of dietary copper to regulate stress-responsive gene for mitigation of multiple stresses in Pangasianodon hypophthalmus

N Kumar, ST Thorat, SR Chavhan - Scientific Reports, 2024 - nature.com
It is an urgent needs to address climate change and pollution in aquatic systems using
suitable mitigation measures to avoid the aquatic animals' extinction. The vulnerability and …

Magnetic borate-modified Mxene: A highly affinity material for the extraction of catecholamines

K Hu, T Pang, Y Shi, P Han, Y Zhao, W Zhao… - Analytica Chimica …, 2021 - Elsevier
A novel magnetic borate-modified MXene composite was prepared by in situ growth of Fe 3
O 4 particles onto the surface of phenylboronic acid modified Ti 3 C 2 T x nanosheets. The …

Microglia and astrocytes in Alzheimer's disease in the context of the aberrant copper homeostasis hypothesis

A Pal, I Rani, A Pawar, M Picozza, M Rongioletti… - Biomolecules, 2021 - mdpi.com
Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …

Strategies for measuring concentrations and forms of amyloid-β peptides

H Shen, K Liu, F Kong, M Ren, X Wang… - Biosensors and …, 2024 - Elsevier
Alzheimer's disease (AD) is affecting more and more people worldwide without the effective
treatment, while the existed pathological mechanism has been confirmed barely useful in …

Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β

J Han, J Yoon, J Shin, E Nam, T Qian, Y Li, K Park… - Nature Chemistry, 2022 - nature.com
The progression of neurodegenerative disorders can lead to impaired neurotransmission;
however, the role of pathogenic factors associated with these diseases and their impact on …

Nano-copper enhances gene regulation of non-specific immunity and antioxidative status of fish reared under multiple stresses

N Kumar, ST Thorat, A Gite, PB Patole - Biological Trace Element …, 2023 - Springer
Arsenic pollution, water temperature, and pH are the major concern for aquaculture.
Moreover, the aim of the present investigation was to delineate the role of nano-copper (Cu …

Construction of a bifunctional near-infrared fluorescent probe for visualization of copper (II) ions and amyloid-β aggregates in Alzheimer's disease

B Wang, J Shi, W Zhai, L Jiang, Y Ma, Z Zhang… - Sensors and Actuators B …, 2025 - Elsevier
Alzheimer's disease (AD) is characterized by multiple interconnected pathological factors,
including the formation of amyloid-β (Aβ) plaques and the abnormal accumulation of copper …