Obesity is an important risk factor for major complications, morbidity and mortality related to
intubation procedures and ventilation in the intensive care unit (ICU). The fall in functional …

The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and
physiological effects with significant implications for critical illness. Changes in respiratory …

There is a well-recognised importance for personalising mechanical ventilation settings to
protect the lungs and the diaphragm for each individual patient. Measurement of …

Rationale: The inspiratory rise in transpulmonary pressure during mechanical ventilation
increases right ventricular (RV) afterload. One mechanism is that when Palv exceeds left …

Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of
respiratory failure. Despite decades of research, there are no effective pharmacologic …

Although maintaining some amount of positive end-expiratory pressure (PEEP) seems
essential, selecting and titrating a specific level for patients with ARDS remains challenging …

Introduction Although there has been extensive research on mechanical ventilation for acute
respiratory distress syndrome (ARDS), treatment remains mainly supportive. Recent studies …

Ventilator-induced lung injury (VILI) is a significant risk for patients with acute respiratory
distress syndrome (ARDS). Management of the patient with ARDS is currently dominated by …

Background Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory
effort (ΔPes), which is the major determinant of self-inflicted lung injury. Research Question …

Rationale: General anesthesia and mechanical ventilation have negative impacts on the
respiratory system, causing heterogeneous distribution of lung aeration, but little is known …