Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

RNA molecules participate in many fundamental cellular processes either as a carrier of
genetic information or as a catalyst, and hence, RNA has received increasing interest both …

The present review summarizes recent publications devoted to aminoglycosides that study
the main types of resistance to antibiotics of this class and the main directions of chemical …

Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics
disturbing protein synthesis through binding to the A site of 16S rRNA. Decades of …

The conjugation of hydrophobic group (s) to the polycationic hydrophilic core of the antibiotic
drugs aminoglycosides (AGs), targeting ribosomal RNA, has led to the development of …

Aminoglycosides are antibiotic drugs that act through binding to rRNA. In the search for
antimicrobial amphiphilic aminoglycosides targeting bacterial membranes, we report here …

Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-
chemical properties and promising applications. Discovered nearly 20 years ago, PNAs …

Amphiphilic aminoglycosides (AAGs) constitute a new class of antibacterial compounds
targeting the bacterial membranes. We have identified the 3′, 6-dinonyl neamine 9 as a …

Natural aminoglycosides are therapeutically useful antibiotics and very efficient RNA
ligands. They are oligosaccharides that contain several ammonium groups able to interfere …