KNDy cells revisited
In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …
[HTML][HTML] Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research
V Sobrino, MS Avendano, C Perdices-Lopez… - Frontiers in …, 2022 - Elsevier
In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …
reproduction occurred with the identification of the reproductive roles of kisspeptins …
Highlights of neuroanatomical discoveries of the mammalian gonadotropin‐releasing hormone system
The anatomy and morphology of gonadotropin‐releasing hormone (GnRH) neurons makes
them both a joy and a challenge to investigate. They are a highly unique population of …
them both a joy and a challenge to investigate. They are a highly unique population of …
Neuroendocrine and Developmental Impacts of Early Life Exposure to EDCs
M Streifer, LM Thompson, SA Mendez… - Journal of the …, 2025 - academic.oup.com
Polychlorinated biphenyls (PCBs) pose a global challenge to environmental and human
health. Although toxic and carcinogenic at higher exposure levels, at lower concentrations …
health. Although toxic and carcinogenic at higher exposure levels, at lower concentrations …
Conditional deletion of KOR (Oprk1) in kisspeptin cells does not alter LH pulses, puberty, or fertility in mice
EA Coutinho, LA Esparza, AD Hudson, N Rizo… - …, 2022 - academic.oup.com
Classic pharmacological studies suggested that endogenous dynorphin-KOR signaling is
important for reproductive neuroendocrine regulation. With the seminal discovery of an …
important for reproductive neuroendocrine regulation. With the seminal discovery of an …
Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and …
Abstract Glucagon-like peptide-1 (GLP-1) regulates reproduction centrally, although, the
neuroanatomical basis of the process is unknown. Therefore, the putative networking of the …
neuroanatomical basis of the process is unknown. Therefore, the putative networking of the …
Importance of neuroanatomical data from domestic animals to the development and testing of the KNDy hypothesis for GnRH pulse generation
Work during the last decade has led to a novel hypothesis for a question that is half a
century old: how is the secretory activity of GnRH neurons synchronized to produce episodic …
century old: how is the secretory activity of GnRH neurons synchronized to produce episodic …
[HTML][HTML] Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1
Regulation of Kiss1 transcription is crucial to the development and function of the
reproductive axis. The homeodomain transcription factor, ventral anterior homeobox 1 …
reproductive axis. The homeodomain transcription factor, ventral anterior homeobox 1 …
Novel actions of kisspeptin signaling outside of GnRH-mediated fertility: a potential role in energy balance
R Patel, JT Smith - Domestic Animal Endocrinology, 2020 - Elsevier
Kisspeptin, encoded by Kiss1 gene expressing neurons in the hypothalamus, is a requisite
for fertility and now appears critical in the regulation of energy balance. Kisspeptin neurons …
for fertility and now appears critical in the regulation of energy balance. Kisspeptin neurons …
Diabetes type 2 and kisspeptin: central and peripheral sex-specific actions
Kisspeptin (KP) plays a major role in the regulation of reproduction governed by the
hypothalamic–pituitary–gonadal (HPG) axis. However, recent findings suggest that the KP …
hypothalamic–pituitary–gonadal (HPG) axis. However, recent findings suggest that the KP …