Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

Several studies on the genetics of longevity have been reviewed in this paper. The results
show that, despite efforts and new technologies, only two genes, APOE and FOXO3A …

Gene variants associated with longevity are also associated with protection against
cognitive decline, dementia and Alzheimer's disease, suggesting that common physiologic …

We performed a genome-wide association study (GWAS) of human extreme longevity (EL),
defined as surviving past the 99th survival percentile, by aggregating data from four …

Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in
findings from previous case-control studies have raised concerns regarding the associations …