Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
[HTML][HTML] Platforms for elucidating antibiotic resistance in single genomes and complex metagenomes
Antibiotic or antimicrobial resistance (AR) facilitated by the vertical and/or horizontal transfer
of antibiotic resistance genes (ARGs), is a serious global health challenge. While …
of antibiotic resistance genes (ARGs), is a serious global health challenge. While …
Microplastics accumulate fungal pathogens in terrestrial ecosystems
Microplastic (MP) is a pervasive pollutant in nature that is colonised by diverse groups of
microbes, including potentially pathogenic species. Fungi have been largely neglected in …
microbes, including potentially pathogenic species. Fungi have been largely neglected in …
Computational approaches for interpreting sc RNA‐seq data
The recent developments in high‐throughput single‐cell RNA sequencing technology (sc
RNA‐seq) have enabled the generation of vast amounts of transcriptomic data at cellular …
RNA‐seq) have enabled the generation of vast amounts of transcriptomic data at cellular …
Genome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance
PF Ma, YL Liu, C Guo, G **, ZH Guo, L Mao… - Nature Genetics, 2024 - nature.com
Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions
between parental genomes in a polyploid nucleus, frequently involving subgenome …
between parental genomes in a polyploid nucleus, frequently involving subgenome …
Assessing vertebrate biodiversity in a kelp forest ecosystem using environmental DNA
JA Port, JL O'Donnell, OC Romero‐Maraccini… - Molecular …, 2016 - Wiley Online Library
Preserving biodiversity is a global challenge requiring data on species' distribution and
abundance over large geographic and temporal scales. However, traditional methods to …
abundance over large geographic and temporal scales. However, traditional methods to …
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
CA Taylor, RA Watson, O Tong, W Ye, I Nassiri… - Nature Medicine, 2022 - nature.com
Abstract Treatment with immune checkpoint blockade (ICB) frequently triggers immune-
related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving …
related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving …
Parallel evolution of cannabinoid biosynthesis
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …
Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells
Y Lubelsky, I Ulitsky - Nature, 2018 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as key parts of multiple cellular pathways,
but their modes of action and how these are dictated by sequence remain unclear. lncRNAs …
but their modes of action and how these are dictated by sequence remain unclear. lncRNAs …
Evolution and host-specific adaptation of Pseudomonas aeruginosa
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant
infections in people with underlying immunodeficiencies or structural lung diseases such as …
infections in people with underlying immunodeficiencies or structural lung diseases such as …