Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies
show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage …

Optical tissue transparency permits scalable cellular and molecular investigation of complex
tissues in 3D. Adult human organs are particularly challenging to render transparent …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

For patients with type 1 diabetes, it is accepted among the scientific community that there is
a marked reduction in β-cell mass; however, with type 2 diabetes, there is disagreement as …

There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-
infiltrating CD8+ leukocytes. Such imaging probes could be used to predict early response …

The interaction between the immune system and endocrine cells in the pancreas is crucial
for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) …

The first pancreaticoduodenectomy was performed in 1909 by Dr Kausch. 1 The procedure
was adapted and popularized by Dr Allen Oldfather Whipple in 1935, who performed only …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …