The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse
cellular processes such as innate immune response, embryogenesis and organ …

As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional
management have highlighted the need for the integration of traditional knowledge systems …

Inflammatory bowel disease (IBD) mainly includes Crohn's disease (CD) and ulcerative
colitis (UC). Immune disorders play an essential role in the pathogenesis of these two IBDs …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Despite the recent successes of targeted cancer immuno-therapies, drug resistance and
disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed …

Cancer, being the second leading cause of mortality, exists as a formidable health
challenge. In spite of our enormous efforts, the emerging complexities in the molecular …

Targeted protein degradation (TPD) has emerged as the most promising approach for the
specific knockdown of disease-associated proteins and is achieved by exploiting the cellular …

Withanolides, and in particular extracts from Withania somnifera, have been used for over
3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within …

Withania somnifera is a traditional Indian herb described under the 'Rasayana'class in
Ayurveda, which gained immense popularity as a dietary supplement in the USA, Europe …

Abstract Background Withaferin-A (WA), an active principle obtained from a traditional Indian
herb known as Ashwagandha or the Indian ginseng, has been shown to prevent and cure …