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Single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
Fluorescent nanoparticles for super-resolution imaging
Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …
wide popularity for visualizing cellular structures with nanometric resolution. Following the …
The cell tracking challenge: 10 years of objective benchmarking
Abstract The Cell Tracking Challenge is an ongoing benchmarking initiative that has
become a reference in cell segmentation and tracking algorithm development. Here, we …
become a reference in cell segmentation and tracking algorithm development. Here, we …
Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes
The goal when imaging bioprocesses with optical microscopy is to acquire the most
spatiotemporal information with the least invasiveness. Deep neural networks have …
spatiotemporal information with the least invasiveness. Deep neural networks have …
Liquid–liquid phase separation drives cellular function and dysfunction in cancer
S Mehta, J Zhang - Nature Reviews Cancer, 2022 - nature.com
Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …
Xanthene, cyanine, oxazine and BODIPY: the four pillars of the fluorophore empire for super-resolution bioimaging
In the realm of biological research, the invention of super-resolution microscopy (SRM) has
enabled the visualization of ultrafine sub-cellular structures and their functions in live cells at …
enabled the visualization of ultrafine sub-cellular structures and their functions in live cells at …
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
Photoswitchable diarylethenes: from molecular structures to biological applications
Z Li, X Zeng, C Gao, J Song, F He, T He, H Guo… - Coordination Chemistry …, 2023 - Elsevier
Diarylethene (DAE) photoswitches, known for their reversible photoinduced cyclization and
cycloreversion reactions, have shown great promise in various fields such as optical data …
cycloreversion reactions, have shown great promise in various fields such as optical data …
Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit
A fundamental challenge in fluorescence microscopy is the photon shot noise arising from
the inevitable stochasticity of photon detection. Noise increases measurement uncertainty …
the inevitable stochasticity of photon detection. Noise increases measurement uncertainty …
StayGold variants for molecular fusion and membrane-targeting applications
R Ando, S Shimozono, H Ago, M Takagi, M Sugiyama… - Nature …, 2024 - nature.com
Although StayGold is a bright and highly photostable fluorescent protein, its propensity for
obligate dimer formation may hinder applications in molecular fusion and membrane …
obligate dimer formation may hinder applications in molecular fusion and membrane …