The small ubiquitin-like modifier (SUMO) signaling cascade is critical for gene expression,
genome integrity, and cell cycle progression. In this review, we discuss the important role …

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and
is essential for the separation of replicated sister chromatids and the integrity of cell division …

Abstract The chemotherapeutic agent 5-fluorouracil (5-FU) remains the backbone of
postoperative adjuvant treatment for gastric cancer. However, fewer than half of patients with …

Conjugation with the small ubiquitin-like modifier (SUMO) modulates protein interactions
and localisation. The kinase Aurora B, a key regulator of mitosis, was previously identified as …

Genomic instability is regarded as a hallmark of cancer cells. It can be presented in many
ways, among which chromosome instability has received attention. Ultrafine anaphase …

Summary DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their
segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome …

Incomplete sister centromere decatenation results in centromeric ultrafine anaphase bridges
(UFBs). PICH (PLK1-interacting checkpoint helicase), a DNA translocase, plays a crucial …

EWSR1 (Ewing sarcoma breakpoint region 1) was originally identified as a part of an
aberrant EWSR1/FLI1 fusion gene in Ewing sarcoma, the second most common pediatric …

Either inhibiting or stabilizing SUMOylation in mitosis causes defects in chromosome
segregation, suggesting that dynamic mitotic SUMOylation of proteins is critical to maintain …

ABSTRACT DNA Topoisomerase II (TopoII) uses ATP hydrolysis to decatenate
chromosomes so that sister chromatids can faithfully segregate in mitosis. When the TopoII …