Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

DQ Huang, P Mathurin, H Cortez-Pinto… - Nature reviews …, 2023 - nature.com
Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-
capita consumption rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to …

Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni, B Gao - The Journal of clinical …, 2024 - jci.org
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

[HTML][HTML] Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer

DQ Huang, AG Singal, Y Kono, DJH Tan, HB El-Serag… - Cell metabolism, 2022 - cell.com
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising
prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) …

[HTML][HTML] Health benefits and side effects of short-chain fatty acids

RG **ong, DD Zhou, SX Wu, SY Huang, A Saimaiti… - Foods, 2022 - mdpi.com
The gut microbiota and their metabolites could play an important role in health and diseases
of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome …

Hepatocellular carcinoma surveillance—utilization, barriers and the impact of changing aetiology

DQ Huang, AG Singal, F Kanwal… - Nature Reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …

The AMPK pathway in fatty liver disease

C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

Changing epidemiology of hepatocellular carcinoma in Asia

C Zhang, Y Cheng, S Zhang, J Fan, Q Gao - Liver International, 2022 - Wiley Online Library
Liver cancer is the fifth most common cancer and the second leading cause of malignant
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …

Microbiome-derived ethanol in nonalcoholic fatty liver disease

AS Meijnikman, M Davids, H Herrema, O Aydin… - Nature medicine, 2022 - nature.com
To test the hypothesis that the gut microbiota of individuals with nonalcoholic fatty liver
disease (NAFLD) produce enough ethanol to be a driving force in the development and …

[HTML][HTML] In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging

T Sun, J Lv, X Zhao, W Li, Z Zhang, L Nie - Photoacoustics, 2023 - Elsevier
We present a rapid and high-resolution photoacoustic imaging method for evaluating the
liver function reserve (LFR). To validate its accuracy, we establish alcoholic liver disease …

Alcohol, inflammation, and microbiota in alcoholic liver disease

M Dukić, T Radonjić, I Jovanović, M Zdravković… - International journal of …, 2023 - mdpi.com
Alcoholic liver disease (ALD) is a consequence of excessive alcohol use. According to many
studies, alcohol represents a significant socioeconomic and health risk factor in today's …