The tumor microenvironment (TME) influences tumor growth, metastatic spread and
response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial …

Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Current mortality due to the Covid-19 pandemic (approximately 1.2 million by November
2020) demonstrates the lack of an effective treatment. As replication of many viruses …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Considerable progress has been made in identifying microenvironmental signals that effect
the reversible phenotypic transitions underpinning the early steps in the metastatic cascade …

Recent evidence has emerged that cancer cells can use various metabolites as fuel
sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote …

Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of
cancer, is considered as a promising therapeutic target against tumors. In chronic …

Abstract Treatment with programmed death-1 (PD-1) blocking antibodies results in high
overall response rates in refractory and relapsed classical Hodgkin lymphoma (cHL) …