Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …

Macrophages play a crucial role in the pathogenesis of atherosclerosis, but the molecular
mechanisms remain poorly understood. Here we show that microRNA-34a (miR-34a) is a …

Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the
risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are …

Circadian rhythms are biological systems that synchronize cellular circadian oscillators with
the organism's daily feeding-fasting or rest-activity cycles in mammals. Circadian rhythms …

The growing recognition of the role of the gut microbiome's impact on alcohol-associated
diseases, especially in alcohol-associated liver disease, emphasizes the need to …

Activating transcription factor (ATF) 3 is known to have an anti-inflammatory function, yet the
role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here …

BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-
hydroxylated bile acids (BAs) that are associated with insulin resistance in humans …