Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …

The brain-derived neurotrophic factor (BDNF) has received considerable attention as a
potential biomarker of major depressive disorder (MDD) and antidepressant response. We …

Background Exercise may improve neuropsychiatric and cognitive symptoms in people with
mental disorders, but the totality of the evidence is unclear. We conducted a meta-review of …

Major depressive disorder (MDD) affects millions of people worldwide and is a leading
cause of disability. Several theories have been proposed to explain its pathological …

Exercise is a well-known non-pharmacological intervention to improve brain functions,
including cognition, memory, and motor coordination. Contraction of skeletal muscles during …

Background Coronary artery disease (CAD) patients undergoing revascularization
procedures often experience ongoing, diminished functional capacity, high rates of …

Depression like many diseases is pleiotropic but unlike cancer and Alzheimer's disease for
example, is still largely stigmatized and falls into the dark shadows of human illness. The …

Growing evidence has shown the beneficial influence of exercise on humans. Apart from
classic cardioprotection, numerous studies have demonstrated that different exercise …

Brain-derived neurotrophic factor (BDNF) is associated with neuronal growth and reduced
BDNF has been implicated in depression. A recent meta-analysis documented reliable …