Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …

The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …

The ability to study cellular physiology using photosensitive, genetically encoded molecules
has profoundly transformed neuroscience. The modern optogenetic toolbox includes …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Calcium imaging is emerging as a popular technique in neuroscience. A major reason is
that intracellular calcium transients are reflections of electrical events in neurons. For …

Motile growth cones lead growing axons through develo** tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

Abstract Information transfer at chemical synapses occurs when vesicles fuse with the
plasma membrane and release neurotransmitter. This process is stochastic and its …