Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

Gene therapy is a promising therapeutic approach for genetic and acquired diseases
nowadays. Among DNA delivery vectors, recombinant adeno‐associated virus (rAAV) is one …

Kinetic modeling is the most suitable framework to describe the dynamic behavior of
mammalian cell culture although its industrial application is still in its infancy. Herein, the …

Current processes for the production of recombinant adeno-associated virus (rAAV) are
inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews …

Chinese hamster ovary (CHO) cells are most prevalently used for producing recombinant
therapeutics in biomanufacturing. Recently, more rational and systems approaches have …

The N-linked glycosylation pattern is an important quality attribute of therapeutic
glycoproteins. It has been reported by our group and by others that different carbon sources …

Machine learning has recently emerged as a promising tool for inferring multi-omic
relationships in biological systems. At the same time, genome-scale metabolic models …

The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells
has revolutionized the treatment of numerous diseases, solidifying their position as a …

As indicated by an ever-increasing number of FDA approvals, biotherapeutics constitute
powerful tools for the treatment of various diseases, with monoclonal antibodies (mAbs) …

Effective bioprocess development using Chinese hamster ovary (CHO) cells as hosts is
hampered by the limited understanding of cellular metabolism under process conditions in …