[HTML][HTML] p53: A tale of complexity and context
M Oren, C Prives - Cell, 2024 - cell.com
The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive
functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are …
functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are …
Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice
R Pourebrahim, RH Montoya, H Akiyama… - Cell Reports …, 2024 - cell.com
The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML)
has been limited by the lack of suitable mouse models, which historically have resulted in …
has been limited by the lack of suitable mouse models, which historically have resulted in …
Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations
account for frequent aberrations in human gastric cancers, neither the sequence nor the …
account for frequent aberrations in human gastric cancers, neither the sequence nor the …
Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth
FL Lv, L Zhang, C Ji, L Peng, M Zhu, S Yang… - Journal of Biological …, 2025 - jbc.org
Inactivation of p53 by mutations commonly occurs in human cancer. The mutated p53
proteins may escape proteolytic degradation and exhibit high expression in tumors and …
proteins may escape proteolytic degradation and exhibit high expression in tumors and …
Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster
T Szlanka, T Lukacsovich, É Bálint… - G3: Genes …, 2024 - academic.oup.com
One of the major functions of programmed cell death (apoptosis) is the removal of cells that
suffered oncogenic mutations, thereby preventing cancerous transformation. By making use …
suffered oncogenic mutations, thereby preventing cancerous transformation. By making use …
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer without effective
treatments. It is characterized by activating KRAS mutations and p53 alterations. However …
treatments. It is characterized by activating KRAS mutations and p53 alterations. However …
Dissecting microRNA-regulated networks in hepatocellular carcinoma cell subtypes with different mutational profiles: Evidence from in vitro and in silico studies
SH Karunakara, V Bhat, M Moorthy, G Ramaswamy… - 2024 - researchsquare.com
Hepatocellular carcinoma (HCC) is a carcinoma of epithelial origin. While there are several
factors, specific genetic and epigenetic landscapes define the initiation and progression of …
factors, specific genetic and epigenetic landscapes define the initiation and progression of …