[HTML][HTML] Forkhead Box O signaling pathway in skeletal muscle atrophy

K Chen, P Gao, Z Li, A Dai, M Yang, S Chen… - The American Journal of …, 2022 - Elsevier
Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis because of disease, aging, and physical inactivity. Patients with skeletal muscle …

5-HT receptors and the development of new antidepressants

G Ślifirski, M Król, J Turło - International journal of molecular sciences, 2021 - mdpi.com
Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …

Acne transcriptomics: fundamentals of acne pathogenesis and isotretinoin treatment

BC Melnik - Cells, 2023 - mdpi.com
This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne
and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin …

[HTML][HTML] Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

K Maiese - Frontiers in bioscience (Landmark edition), 2021 - ncbi.nlm.nih.gov
Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …

Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging

CM Gendron, TS Chakraborty, C Duran, T Dono… - PLoS …, 2023 - journals.plos.org
Sensory perception modulates aging, yet we know little about how. An understanding of the
neuronal mechanisms through which animals orchestrate biological responses to relevant …

Changes in multiple microRNA levels with antidepressant treatment are associated with remission and interact with key pathways: a comprehensive microRNA …

T Funatsuki, H Ogata, H Tahara, A Shimamoto… - International Journal of …, 2023 - mdpi.com
Individual treatment outcomes to antidepressants varies widely, yet the determinants to this
difference remain elusive. MicroRNA (miRNA) gene expression regulation in major …

Lasia spinosa (L.) thw. attenuates chemically induced behavioral disorders in experimental and computational models

ASMA Reza, MA Sakib, MS Nasrin, J Khan, MF Khan… - Heliyon, 2023 - cell.com
Abstract Lasia spinosa (L.) Thw.(L. spinosa) is widely used as a folk remedy for different
physical ailments, and its neurological effects have yet to be assessed. Phytochemicals …

[HTML][HTML] Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking

X Zhang, M Wang, Y Qiao, Z Shan, M Yang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Depression is the most common type of psychological disorder, with
continuous, prolonged, and persistent bad moods as the main clinical feature. Cordyceps …

Stroke Related Brain–Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms

X Fan, J Cao, M Li, D Zhang, I El‐Battrawy… - Advanced …, 2024 - Wiley Online Library
The emergence of acute ischemic stroke (AIS) induced cardiovascular dysfunctions as a
bidirectional interaction has gained paramount importance in understanding the intricate …

Exploring the role of biologics in depression

T Rani, T Behl, N Sharma, HA Makeen, M Albratty… - Cellular …, 2022 - Elsevier
Depression is a chronic and prevalent neuropsychiatric disorder; clinical symptoms include
excessive sad mood, anhedonia, increased anxiety, disturbed sleep, and cognitive deficits …