Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

Certain neurons in the mammalian brain have long been known to be joined by gap
junctions, which are the most common type of electrical synapse. More recently, cloning of …

Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Connexin 43 (Cx43) nonjunctional or “unapposed” hemichannels can open under
physiological or pathological conditions. We characterize hemichannels comprised of Cx43 …

Connexins, the protein molecules forming gap junction channels, are reduced in number or
redistributed from intercalated disks to lateral cell borders in a variety of cardiac diseases …

Gap junctions are clusters of aqueous channels that connect the cytoplasm of adjoining
cells. Each cell contributes a hemichannel, or connexon, to each cell–cell channel. The cell …

Regulation of gap junction (GJ) organization is critical for proper function of excitable tissues
such as heart and brain, yet mechanisms that govern the dynamic patterning of GJs remain …

Certain membrane channels including acetylcholine receptors, gap junction (GJ) channels,
and aquaporins arrange into large clusters in the plasma membrane (PM). However, how …

Over the last two decades, the view of gap junction (GJ) channel gating has changed from
one with GJs having a single transjunctional voltage-sensitive (Vj-sensitive) gating …