In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced
selectivity and protection against overdosage. However, we need to better understand …

Methods rooted in chemical biology have contributed significantly to studies of integral
membrane proteins. One recent key approach has been the application of genetic code …

Affinity chromatography is the method of choice for the rapid purification of proteins from cell
extracts or culture supernatants. Here, we present the light-responsive Azo-tag, a short …

Photopharmacology is a novel technology in drug design that aims at solving poor drug
selectivity. This technology is currently in the proof-of-concept phase and relies on the …

Light is essential for various biochemical processes in all domains of life. In its presence
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …

Dynamic control over protein function is a central challenge in synthetic biology. To address
this challenge, we describe the development of an integrated computational and …

The overall significance of loop motions for enzymatic activity is generally accepted.
However, it has largely remained unclear whether and how such motions can control …