The initiation of V (D) J recombination by the recombination activating gene 1 (RAG1) and
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …

Fish is considered to be an important model in comparative immunology studies because it
is a representative population of lower vertebrates serving as an essential link to early …

The ability to maintain quiescence is critical for the long-term maintenance of a functional
stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem …

Chromosomal translocations involving antigen receptor loci are common in lymphoid
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …

A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …

The critical initial step in V (D) J recombination, binding of RAG1 and RAG2 to
recombination signal sequences flanking antigen receptor V, D, and J gene segments, has …

The allelic exclusion of immunoglobulin (Ig) genes is one of the most evolutionarily
conserved features of the adaptive immune system and underlies the monospecificity of B …

In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple
cancer forms. The aberrant high levels observed in cancer tissue have been associated with …

Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially
expressed Cμ (IgM) constant regions (CH) exons with downstream CH exons. Stimulation of …