Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …

Since diabetic cardiomyopathy was first reported four decades ago, substantial information
on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances …

A strict bidirectional relationship exists between diabetes mellitus (DM) and heart failure
(HF). DM is common in HF patients with a prevalence range from 10% to 30%, and up to …

Arterial stiffening is a progressive, ubiquitous and irreversible aging process that is
interwoven with and accelerated by various diseases such as diabetes, atherosclerosis and …

The process of advanced glycation leads to the generation and accumulation of an
heterogeneous class of molecules called advanced glycation endproducts, or AGEs. AGEs …

Heart failure in patients with diabetes has been recognised since 1876. 1 The
cardiovascular harm of thiazolidinediones shone the 21st century spotlight on the interaction …

The prevalence of obesity in the United States has reached epidemic proportions. As a
consequence, obesity-related diseases, such as diabetes, also continue to increase at a …

Patients with diabetes have an increased risk for development of cardiomyopathy, even in
the absence of well known risk factors like coronary artery disease and hypertension …

The presence of comorbidities significantly influences long-term morbidity and mortality of
symptomatic and asymptomatic heart failure (HF) patients. Metabolic syndrome and diabetic …