Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data

M Carilli, G Gorin, Y Choi, T Chari, L Pachter - Nature Methods, 2024‏ - nature.com
Here we present biVI, which combines the variational autoencoder framework of scVI with
biophysical models describing the transcription and splicing kinetics of RNA molecules. We …

Approximating solutions of the chemical master equation using neural networks

A Sukys, K Öcal, R Grima - Iscience, 2022‏ - cell.com
Summary The Chemical Master Equation (CME) provides an accurate description of
stochastic biochemical reaction networks in well-mixed conditions, but it cannot be solved …

DelaySSAToolkit. jl: stochastic simulation of reaction systems with time delays in Julia

X Fu, X Zhou, D Gu, Z Cao, R Grima - Bioinformatics, 2022‏ - academic.oup.com
DelaySSAToolkit. jl is a Julia package for modelling reaction systems with non-Markovian
dynamics, specifically those with time delays. These delays implicitly capture multiple …

Transient and delay chemical master equations

G Gorin, S Yoshida, L Pachter - bioRxiv, 2022‏ - biorxiv.org
The serial nature of reactions involved in the RNA life-cycle motivates the incorporation of
delays in models of transcriptional dynamics. The models couple a bursty or switching …

[كتاب][B] Stochastic foundations for single-cell RNA sequencing

G Gorin - 2023‏ - search.proquest.com
Single-cell RNA sequencing, which quantifies cell transcriptomes, has seen widespread
adoption, accompanied by proliferation of analysis methods. However, there has been …