Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian
tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …

Abstract Frailty and Biological Age are two closely related concepts; however, frailty is a
multisystem geriatric syndrome that applies to elderly subjects, whereas biological age is a …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Epigenetic clocks, built on DNA methylation patterns of bulk tissues, are powerful age
predictors, but their biological basis remains incompletely understood. Here, we conducted …

Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity
for tissue regeneration, and an increased risk of age-related diseases and mortality. A …