A review of methods and databases for metagenomic classification and assembly

FP Breitwieser, J Lu, SL Salzberg - Briefings in bioinformatics, 2019 - academic.oup.com
Microbiome research has grown rapidly over the past decade, with a proliferation of new
methods that seek to make sense of large, complex data sets. Here, we survey two of the …

Metagenomic approaches in microbial ecology: an update on whole-genome and marker gene sequencing analyses

AE Pérez-Cobas, L Gomez-Valero… - Microbial …, 2020 - microbiologyresearch.org
Metagenomics and marker gene approaches, coupled with high-throughput sequencing
technologies, have revolutionized the field of microbial ecology. Metagenomics is a culture …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Combinatorial, additive and dose-dependent drug–microbiome associations

SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

The gut microbiota in prediabetes and diabetes: a population-based cross-sectional study

H Wu, V Tremaroli, C Schmidt, A Lundqvist, LM Olsson… - Cell metabolism, 2020 - cell.com
The link between the gut microbiota and type 2 diabetes (T2D) warrants further investigation
because of known confounding effects from antidiabetic treatment. Here, we profiled the gut …

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

J Wirbel, PT Pyl, E Kartal, K Zych, A Kashani… - Nature medicine, 2019 - nature.com
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross …

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

S Vieira-Silva, G Falony, E Belda, T Nielsen… - Nature, 2020 - nature.com
Microbiome community ty** analyses have recently identified the Bacteroides 2 (Bact2)
enterotype, an intestinal microbiota configuration that is associated with systemic …

Extensive impact of non-antibiotic drugs on human gut bacteria

L Maier, M Pruteanu, M Kuhn, G Zeller, A Telzerow… - Nature, 2018 - nature.com
A few commonly used non-antibiotic drugs have recently been associated with changes in
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we …

Recovery of gut microbiota of healthy adults following antibiotic exposure

A Palleja, KH Mikkelsen, SK Forslund, A Kashani… - Nature …, 2018 - nature.com
To minimize the impact of antibiotics, gut microorganisms harbour and exchange antibiotics
resistance genes, collectively called their resistome. Using shotgun sequencing-based …

dbCAN2: a meta server for automated carbohydrate-active enzyme annotation

H Zhang, T Yohe, L Huang, S Entwistle… - Nucleic acids …, 2018 - academic.oup.com
Complex carbohydrates of plants are the main food sources of animals and microbes, and
serve as promising renewable feedstock for biofuel and biomaterial production …